Protein Details: Voltage gated channel-like protein 1
Protein ID
ICDB_Pro_1257
Protein Name
Voltage gated channel-like protein 1
Gene Name
NALCN; VGCNL1
Organism
Homo sapiens (Human)
Length
1738 amino acids
AlphaFoldDB
AF-Q8IZF0-F1-model_v4.pdb
Function
Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability . NALCN channel functions as a multi-protein complex; which consists at least of NALCN; NALF1; UNC79 and UNC80 . NALCN is the voltage-sensing; pore-forming subunit of the NALCN channel complex . NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations . In addition to its role in regulating neuronal excitability; is required for normal respiratory rhythm; systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition; NALCN activity is enhanced/modulated by several GPCRs; such as CHRM3 (By similarity).
Sequence
Ligand Binding
Binding Site
Disease
Congenital Contractures Of The Limbs And Face;Hypotonia;And Developmental Delay and Hypotonia;Infantile;With Psychomotor Retardation And Characteristic Facies 1